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Institution: Lund University Lund University was founded in 1666 and is repeatedly ranked among the world’s top universities. The University has around 46 000 students and 8 500 staff based in Lund, Helsingborg and Malmö. We are united in our efforts to understand, explain and improve our world and the human condition. Description of the WorkplaceWe are looking for a PhD student in molecular genetics interested in contributing to a better understanding of the molecular mechanisms that maintain telomeres. The research group is part of the Molecular Biosciences division at the Department of Biology. This is a molecular biology environment where we are studying the molecular details of various cellular life processes. Being a Doctoral StudentAs a doctoral student, you are both admitted as a student and employed at Lund University. As a doctoral student, you will be trained in a scientific approach. In short, you will be trained to think critically and analytically, to solve problems independently using the right methods, and to develop an awareness of research ethics. In addition, you will have the opportunity to work on projects, to develop your leadership and pedagogical skills. Throughout your studies, you will be guided by supervisors. Doctoral studies end with a thesis and a doctoral degree. More about being a doctoral student at the Faculty of Science: naturvetenskap.se Doctoral studies | Faculty of Science Subject and Project DescriptionYou will join the research group of Marita Cohn, in the subject area of Molecular Genetics, as part of the Molecular Biosciences division. The research topic encompasses fundamental research on molecular mechanisms that are responsible for the maintenance of telomere function in eukaryotic model systems. Telomeres are the chromatin structures protecting the ends of chromosomes and are normally maintained by the enzyme telomerase. However, telomerase-deficient cells may restore telomere function by using recombination-based pathways, so-called Alternative Lengthening of Telomeres (ALT). The PhD project will focus on elucidation of the genetic requirements and the molecular mechanisms responsible for the maintenance of telomeres in yeast cells, where both telomerase-dependent and ALT pathways are involved. In this project, you will perform laboratory experiments using various molecular biology and biochemical methods and molecular genetic approaches. Moreover, to elucidate the telomere maintenance mechanisms, you will employ bioinformatics and computational analyses of DNA and RNA sequences. Link to general study plan for Biology: Study plan Work DutiesYou will primarily devote yourself to your doctoral education, which mainly consists of writing a doctoral thesis. Within the research project you will use different methods to study the molecular processes of telomere maintenance in detail, perform data analysis, summarize the results and study the scientific literature. You are expected to contribute to the planning, execution and analysis of the experiments, as well as to writing of scientific papers and grant applications. As a researcher, you will also present your research results by participating in seminars and international conferences. You are expected to collaborate with other PhD students/students on experiments, as well as supervise undergraduate students and interns in the laboratory. The doctoral training also includes some mandatory courses and voluntary special courses that contribute to your development in solving and presenting scientific questions. In addition to studies, a maximum of 20% of working time may be spent on teaching and other departmental work. You will participate in the teaching of Molecular Genetics, participate in organizing the laboratory, as well as handle administrative duties and project economy. QualificationsAdmission RequirementsA person meets the general admission requirements for third-cycle courses and study programmes if the applicant:
A person meets the specific admission requirements for third cycle studies in Biology if the applicant has:
Additional Requirements
Selection CriteriaSelection will be based on:
We OfferLund University is a public authority offering generous benefits, annual leave, and occupational pension schemes. The department provides an inclusive, dynamic, and creative environment with well-equipped laboratories, seminars, and international collaboration opportunities. More information: https://www.lunduniversity.lu.se/about-university/work-lund-university Employment
ContactMarita Cohn, Senior Lecturer Application Requirements
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