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All-optical nanosizing and sensing has traditionally relied on particle-scattering techniques, which infer nanoparticle characteristics. While effective, these methods lack the ability to measure molecular composition, making it impossible to distinguish target analytes from contaminants, a serious limitation. Unlocking molecular-level information at the nanoscale would enable accurate, label-free sensing in complex biomedical samples, thus transforming current approaches. To give a few examples, molecularly resolved nanoscopy would allow us to quantify drug loading in nanomedicines, measure nucleic acids in viruses, and monitor nanocatalyst turnover. During this 30-month postdoctoral fellowship, you will provide the technology: all-optical, label-free single-particle nanoscopy in the DUV, in direct resonance with electronic transitions.This innovative approach will offer analyte-specific insights and significantly boost signal levels. The clear and ambitious goal is to deliver technologies that not only surpass current gold-standard methods but also enable measurements that were previously unattainable. Beyond proof-of-concept demonstrations, the project aims to establish DUV-based nanosizing as a viable, adaptable methodology. To achieve this, we will develop low-cost hyperspectral DUV imaging approaches combining holographic imaging with Fourier transform methods, enabled by a broadly tunable DUV light source. With the support of our interdisciplinary team, you will take a leading role in this ambitious project and:
Your profileThe ideal candidate will have a strong background in experimental nanophotonics, all-optical sensing or label-free microscopy.
What do we offer?A fully funded one year postdoctoral fellowship with ample room for personal development in a socially engaged organisation. We offer:
We also offer you attractive fringe benefits and regulations. Some examples:
About usThe MatzLab develops next-generation imaging and sensing platforms in the context of future biomedical, pharmaceutical, and clinical applications. We are particularly interested in label-free or digital approaches, where we combine fundamental research with systematic platform and assay development. To realise our vision, we build on an interdisciplinary toolbox comprising molecular biology, ultrafast optics, advanced microscopy, and nanophotonics, with the key ingredient being creativity and room for personal development. Faculty of Science We work on new solutions guided by value-driven, interdisciplinary methodologies. We are committed to research, valorisation and training socially engaged citizens of the world who will make valuable contributions to a sustainable, healthy future. Are you interested in joining the Faculty of Science? You will join undergraduate students, PhD candidates and researchers at the biggest sciences faculty in the Netherlands. You will combine a professional focus with a broad view of the world. We are proud of our collegial working climate, characterised by committed staff, a pragmatic attitude and engagement in the larger whole. The faculty is home to over 11,000 students enrolled in 40 study programmes. It employs over 1,600 professionals spread across 10 academic departments. Vrije Universiteit Amsterdam We are located on one physical campus, in the heart of Amsterdam's Zuidas business district, with excellent location and accessibility. Over 5,500 staff work at the VU and over 30,000 students attend academic education. Diversity We stand for an inclusive community and believe that diversity and internationalisation contribute to the quality of education, research and our services. Therefore, we are always searching for people whose backgrounds and experience contribute to the diversity of the VU community. Interested
Evaluation will be done on a rolling basis until the vacancy is filled. Any questions prior to applying? Please directly contact Matz Liebel. Applications received by e-mail will not be considered. Acquisition in response to this advertisement is not appreciated.
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