Postdoctoral Associate in Pediatrics (Duke University)

Position Title Location: Durham, NC, US, 27710 Personnel Area: Medical Center Requisition Number: 264160 Regular or Temporary: Regular Date Posted: Dec 10, 2025 School Overview Established in 1930, Duke University School of Medicine is the youngest of the nation's top medical schools. Ranked sixth among medical schools in the nation, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where interdisciplinary collaboration is embraced and great ideas accelerate translation of fundamental scientific discoveries to improve human health locally and globally. Composed of more than 2,500 faculty physicians and researchers, more than 1,300 students, and more than 6,000 staff, Duke University School of Medicine along with the Duke University School of Nursing, Duke University Health System and the Private Diagnostic Clinic (PDC) comprise Duke Health, a world-class academic medical center. The Health System encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Primary Care, Duke Home and Hospice, Duke Health and Wellness, and multiple affiliations. Occupational Summary We are looking for an energetic and motivated individual to join our childhood cancer translational research team. We study a pediatric skeletal muscle solid tumor called rhabdomyosarcoma, and have a mandate by the NIH to inform new therapies for this difficult-to-treat disease. Focus is on understanding how corrupt coding and non-coding (“dark genome”) genes that are part of developmental signaling pathways (Notch, Hippo) support tumorigenesis and might reveal novel therapeutic vulnerabilities. Every project incorporates the evaluation of novel pharmacologic agents to shepherd to early phase clinical trials. We collaborate with investigators intramurally (Duke Pharmacology & Cancer Biology, Cell Biology, Biomedical Engineering), and extramurally nationally and internationally. Being independent and able to interface with multiple work groups is critical. We use biochemical, proteomic, cell biology, molecular biology, genomic, epigenomic, and mouse model approaches and collaborate with groups using artificial intelligence approaches and next-gen chemistry. We value teamwork, creativity, resilience, and patient advocacy. A two-year commitment (or beyond) is preferred. Lab website: https://sites.duke.edu/corinnelinardiclab/ Work Performed / Responsibilities Perform literature reviews to guide research Design and execution of standard in vitro assays (transient or stable expression of cDNA/shRNAs/CRISPR, mutagenesis, IPs, immunoblotting, nucleic acid extractions, PCR, phenotype-based cell assays including proliferation, apoptosis, myogenic differentiation, etc.) Design and implementation of in vitro and in vivo ‘omics screens, with input from Duke Functional Genomics, Sequencing, and Proteomics cores Participation in in vivo murine pre-clinical studies (SQ and orthotopic xenografts) and tumor tissue analyses including immunohistochemistry and preparation for NGS Application of statistically sound analyses Participation in drafting of LOIs, grant applications, abstracts, posters, and manuscripts Participation and presentation in domestic/international childhood cancer think tank meetings Functioning as a resource for early stage scientists (graduate students and technicians) Applying creative and independent thinking to advance research on this difficult-to-cure cancer Required Qualifications PhD (or doctoral degree equivalent) in Biochemistry, Genetics, or Cell/Molecular Biology with a record of publication in peer-reviewed journals (preferred). Candidates with expertise in cancer biology are encouraged to apply Ability to perform molecular and cellular protocols including nucleic acid isolation, qPCR, cloning, mutagenesis, cell culture, protein lysate generation, immunoblot, and lentiviral-based protocols Willingness to learn mouse protocols for cancer research Excellent oral and written communication skills Excellent self-motivation, organizational skills, creativity, and ability to work independently and in a team How to Apply Candidates with a PhD, MD, or MD-PhD degree and a minimum of one first-author publication should send their CV, a brief letter of research interest, and three references to: Corinne Linardic, MD PhD Email: corinne.linardic@duke.edu Equal Opportunity Statement Duke is an Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex (including pregnancy and pregnancy-related conditions), sexual orientation, or military status. Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. All members of our community are expected to uphold these values. Essential Physical Job Functions Certain jobs at Duke University and Duke University Health System may include essential job functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department. Nearest Major Market: Durham Nearest Secondary Market: Raleigh If you apply for this position please say you saw it on Academicoxy

Position Title

Location: Durham, NC, US, 27710
Personnel Area: Medical Center
Requisition Number: 264160
Regular or Temporary: Regular
Date Posted: Dec 10, 2025

School Overview

Established in 1930, Duke University School of Medicine is the youngest of the nation's top medical schools. Ranked sixth among medical schools in the nation, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where interdisciplinary collaboration is embraced and great ideas accelerate translation of fundamental scientific discoveries to improve human health locally and globally.

Composed of more than 2,500 faculty physicians and researchers, more than 1,300 students, and more than 6,000 staff, Duke University School of Medicine along with the Duke University School of Nursing, Duke University Health System and the Private Diagnostic Clinic (PDC) comprise Duke Health, a world-class academic medical center. The Health System encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Primary Care, Duke Home and Hospice, Duke Health and Wellness, and multiple affiliations.

Occupational Summary

We are looking for an energetic and motivated individual to join our childhood cancer translational research team. We study a pediatric skeletal muscle solid tumor called rhabdomyosarcoma, and have a mandate by the NIH to inform new therapies for this difficult-to-treat disease. Focus is on understanding how corrupt coding and non-coding (“dark genome”) genes that are part of developmental signaling pathways (Notch, Hippo) support tumorigenesis and might reveal novel therapeutic vulnerabilities. Every project incorporates the evaluation of novel pharmacologic agents to shepherd to early phase clinical trials.

We collaborate with investigators intramurally (Duke Pharmacology & Cancer Biology, Cell Biology, Biomedical Engineering), and extramurally nationally and internationally. Being independent and able to interface with multiple work groups is critical. We use biochemical, proteomic, cell biology, molecular biology, genomic, epigenomic, and mouse model approaches and collaborate with groups using artificial intelligence approaches and next-gen chemistry. We value teamwork, creativity, resilience, and patient advocacy. A two-year commitment (or beyond) is preferred.

Lab website: https://sites.duke.edu/corinnelinardiclab/

Work Performed / Responsibilities

Perform literature reviews to guide research
Design and execution of standard in vitro assays (transient or stable expression of cDNA/shRNAs/CRISPR, mutagenesis, IPs, immunoblotting, nucleic acid extractions, PCR, phenotype-based cell assays including proliferation, apoptosis, myogenic differentiation, etc.)
Design and implementation of in vitro and in vivo ‘omics screens, with input from Duke Functional Genomics, Sequencing, and Proteomics cores
Participation in in vivo murine pre-clinical studies (SQ and orthotopic xenografts) and tumor tissue analyses including immunohistochemistry and preparation for NGS
Application of statistically sound analyses
Participation in drafting of LOIs, grant applications, abstracts, posters, and manuscripts
Participation and presentation in domestic/international childhood cancer think tank meetings
Functioning as a resource for early stage scientists (graduate students and technicians)
Applying creative and independent thinking to advance research on this difficult-to-cure cancer

Required Qualifications

PhD (or doctoral degree equivalent) in Biochemistry, Genetics, or Cell/Molecular Biology with a record of publication in peer-reviewed journals (preferred). Candidates with expertise in cancer biology are encouraged to apply
Ability to perform molecular and cellular protocols including nucleic acid isolation, qPCR, cloning, mutagenesis, cell culture, protein lysate generation, immunoblot, and lentiviral-based protocols
Willingness to learn mouse protocols for cancer research
Excellent oral and written communication skills
Excellent self-motivation, organizational skills, creativity, and ability to work independently and in a team

How to Apply

Candidates with a PhD, MD, or MD-PhD degree and a minimum of one first-author publication should send their CV, a brief letter of research interest, and three references to:

Corinne Linardic, MD PhD
Email: corinne.linardic@duke.edu

Equal Opportunity Statement

Duke is an Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex (including pregnancy and pregnancy-related conditions), sexual orientation, or military status.

Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. All members of our community are expected to uphold these values.

Essential Physical Job Functions

Certain jobs at Duke University and Duke University Health System may include essential job functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.

Nearest Major Market: Durham
Nearest Secondary Market: Raleigh

If you apply for this position please say you saw it on Academicoxy

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