Postdoc Position in Physics (VU University of Amsterdam)

Your Function Project Description Due to ageing, the impact of vision-threatening diseases such as diabetic retinopathy (DR) and age-related macular degeneration (AMD) on the health care system will only increase. In this project, we will develop techniques to quantitatively assess the oxygen saturation status of the retinal microvasculature. Reduced blood oxygen levels may lead to hypoxia, which is one of the key drivers of the formation of new blood vessels. These new blood vessels are often leaky, leading to complications such as vision loss and, ultimately, blindness. Detecting the onset of retinal hypoxia will allow timely therapeutic interventions to prevent vision loss. In this collaborative project between VU Amsterdam, TNO, and Heidelberg Engineering, we will develop a multi-color scanning laser ophthalmoscope (mcSLO)-based oximeter with retro-illumination capabilities. The retro-mode mcSLO will be a versatile research tool, providing freedom in selecting imaging wavelengths and allowing different implementations of light delivery and collection to and from the retina. We will develop novel image analysis algorithms for retro-mode imaging to quantify the wavelength-dependent scattering and absorption properties of the retina, from which microvascular oxygen saturation can be calculated. The algorithms will partly rely on Monte Carlo simulations of light transport in the retina. The system and algorithm performance will be validated on model eyes with controlled scattering and absorption properties. Tasks We are looking for a PostDoc who will: Work on optical instrumentation, image analysis algorithms, and technical validation on model eyes Develop a retro-mode illumination and detection module and integrate it into an existing custom-built mcSLO system Perform tests on model eyes and analyze the results as a first technical validation of the system The research will be conducted at VU Amsterdam. The candidate will be part of the Biomedical Physics Group, under the supervision of Prof. dr. J.F. de Boer and Prof. dr. A. Amelink. Your Profile Requirements: PhD in (applied) physics or a related field Strong interest in biomedical optics Good experimental skills Ability to communicate effectively in English, both verbally and in writing Additional Information: Results of the project will be presented at national and international medical and technical conferences and published in relevant journals VU Amsterdam strives for equal opportunities and values diversity in all its forms Candidates from diverse backgrounds are encouraged to apply, even if not all requirements are fully met What Do We Offer? Salary: €3,546 – €5,538 gross per month (Scale 10), based on education and experience, full-time basis, UFO profile Researcher 4 Employment: At least 0.8 FTE; initial contract for 1 year with the possibility of expansion Fringe Benefits: 38-hour working week with 232 hours holiday leave per year (pro-rata for part-time) 8% holiday allowance and 8.3% end-of-year bonus Contribution to commuting expenses Optional personalized benefits package Access to a wide range of sports facilities at a modest charge About Us Department of Physics and Astronomy, VU Amsterdam Research focused on high-energy & gravitational physics, quantum metrology & laser applications, physics of life & health, physics of photosynthesis & energy Teaching in Physics & Astronomy, Science Business & Innovation, Medical Natural Sciences, and Mechanical Engineering programs Strong track record in translational research, collaborations with industry, and startup initiatives Faculty of Science Collaborative, interdisciplinary environment addressing complex societal challenges 8,000+ students across 39 programs and 1,400+ staff across 10 scientific departments Vrije Universiteit Amsterdam Values-driven, open-minded, inclusive, and socially impactful education and research Located on a single campus in Amsterdam's Zuidas business district 6,150+ staff and 31,000+ students Diversity & Inclusion VU Amsterdam values diversity in disciplines, cultures, ideas, nationalities, beliefs, preferences, and worldviews Inclusive community contributing to the quality of education, research, and services Interested? If you believe your experience will contribute to our university, please submit: A letter describing your abilities and motivation Detailed curriculum vitae (CV) with two or three references Diploma and list of grades TOEFL and/or IELTS scores (if available) Sample of a written report in English Note: Applications received by e-mail will not be considered. Acquisition in response to this advertisement is not appreciated. Contact Prof. dr. Johannes F. de Boer Professor of Biophotonics and Medical Imaging Email: [Contact via email] If you apply for this position please say you saw it on Academicoxy

Your Function

Project Description

Due to ageing, the impact of vision-threatening diseases such as diabetic retinopathy (DR) and age-related macular degeneration (AMD) on the health care system will only increase.

In this project, we will develop techniques to quantitatively assess the oxygen saturation status of the retinal microvasculature. Reduced blood oxygen levels may lead to hypoxia, which is one of the key drivers of the formation of new blood vessels. These new blood vessels are often leaky, leading to complications such as vision loss and, ultimately, blindness. Detecting the onset of retinal hypoxia will allow timely therapeutic interventions to prevent vision loss.

In this collaborative project between VU Amsterdam, TNO, and Heidelberg Engineering, we will develop a multi-color scanning laser ophthalmoscope (mcSLO)-based oximeter with retro-illumination capabilities. The retro-mode mcSLO will be a versatile research tool, providing freedom in selecting imaging wavelengths and allowing different implementations of light delivery and collection to and from the retina. We will develop novel image analysis algorithms for retro-mode imaging to quantify the wavelength-dependent scattering and absorption properties of the retina, from which microvascular oxygen saturation can be calculated. The algorithms will partly rely on Monte Carlo simulations of light transport in the retina. The system and algorithm performance will be validated on model eyes with controlled scattering and absorption properties.

Tasks

We are looking for a PostDoc who will:

Work on optical instrumentation, image analysis algorithms, and technical validation on model eyes
Develop a retro-mode illumination and detection module and integrate it into an existing custom-built mcSLO system
Perform tests on model eyes and analyze the results as a first technical validation of the system

The research will be conducted at VU Amsterdam. The candidate will be part of the Biomedical Physics Group, under the supervision of Prof. dr. J.F. de Boer and Prof. dr. A. Amelink.

Your Profile

Requirements:

PhD in (applied) physics or a related field
Strong interest in biomedical optics
Good experimental skills
Ability to communicate effectively in English, both verbally and in writing

Additional Information:

Results of the project will be presented at national and international medical and technical conferences and published in relevant journals
VU Amsterdam strives for equal opportunities and values diversity in all its forms
Candidates from diverse backgrounds are encouraged to apply, even if not all requirements are fully met

What Do We Offer?

Salary: €3,546 – €5,538 gross per month (Scale 10), based on education and experience, full-time basis, UFO profile Researcher 4
Employment: At least 0.8 FTE; initial contract for 1 year with the possibility of expansion

Fringe Benefits:

38-hour working week with 232 hours holiday leave per year (pro-rata for part-time)
8% holiday allowance and 8.3% end-of-year bonus
Contribution to commuting expenses
Optional personalized benefits package
Access to a wide range of sports facilities at a modest charge

About Us

Department of Physics and Astronomy, VU Amsterdam

Research focused on high-energy & gravitational physics, quantum metrology & laser applications, physics of life & health, physics of photosynthesis & energy
Teaching in Physics & Astronomy, Science Business & Innovation, Medical Natural Sciences, and Mechanical Engineering programs
Strong track record in translational research, collaborations with industry, and startup initiatives

Faculty of Science

Collaborative, interdisciplinary environment addressing complex societal challenges
8,000+ students across 39 programs and 1,400+ staff across 10 scientific departments

Vrije Universiteit Amsterdam

Values-driven, open-minded, inclusive, and socially impactful education and research
Located on a single campus in Amsterdam's Zuidas business district
6,150+ staff and 31,000+ students

Diversity & Inclusion

VU Amsterdam values diversity in disciplines, cultures, ideas, nationalities, beliefs, preferences, and worldviews
Inclusive community contributing to the quality of education, research, and services