The Lengefeld laboratory is working on understanding how the failure to regenerate tissue with age is a major health issue. A contributor to this decline is the loss of stem cell function. Despite the essential role of stem cells, it is still unclear how they fail to maintain their functions during aging and disease. We discovered a new aspect of stem cell aging in vivo: cellular enlargement. With age and damage, stem cells increase in size causing their functional decline. However, we are only beginning to understand how size impacts stem cell fitness and the physiological importance of this process remains unsolved.
Due Date: 15.2.2025
Unit: Helsinki Institute of Life Science
Sub-unit: Institute of Biotechnology
ID: 3750
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